(for veterinary information only)
BRAND NAME: SIMPLICEF, VANTIN
But quickly, it became obvious that this new "wonder drug" could bear improvement. For example:
The Cephalosporin class was developed to improve upon the accomplishments of the penicillin class. The first group developed (the so-called "First Generation Cephalosporins") is effective against most Gram positive infections, some Gram negative infections and is able to withstand the anti-penicillin enzymes produced by Staphylococci.
The "Second Generation Cephalosporins" have an increased spectrum against Gram negative bacteria and the "Third Generation Cephalosprorins" are effective against still more Gram negative bacteria. Cefpodoxime is a third generation cephalosporin and one of the few that can be administered orally. It was released for veterinary use in the earlier part of 2005.
HOW THIS MEDICATION IS USED
The beauty of cefpodoxime is twofold: it is available for oral use AND it is given only once a day. Its recommended dosing schedule is flexible with lower doses recommended for tissues where the drug is readily concentrated (such as in urine for treatment of a bladder infection, or abscesses/wounds) and higher ones for tissues where the drug is not as well concentrated (such as ear infections). Because of its ability to treat more complicated infections, it is often selected for jobs where other antibiotics are expected to fail. Since its release as a veterinary product it has gained popularity especially in veterinary dermatology where Staphylococcal infections are common and treatment durations of several weeks are routine.
Cefpodoxime can be given on a full or empty stomach with no change in efficacy.
Approximately 2% of dogs taking this medication experience vomiting, 1% experience diarrhea, and 1% experience reduced appetite.
INTERACTIONS WITH OTHER DRUGS
Drugs that decrease stomach acidity (any antacids) may decrease absorption and thus efficacy of cefpodoxime.
CONCERNS AND CAUTIONS
Page last updated: 5/8/2012