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Flea Product Comparison
Confused about flea protection? This FAQ compares all the currently available flea control products to assist you in determining which is right for your situation. These products are available at licensed veterinary hospitals. If you would like to know why we haven’t included over the counter products (as would be sold in a grocery or pet supply store), click here. Because there are 27 different products compared in 16 different categories, we have split up the information into 4 separate tables.
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Table 1:
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Flea killing ingredient; Flea sterilizing or additional ingredients; For dogs or cats; Youngest age or size approved for use; Waterproof or water resistant
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Table 2:
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Approved for pregnancy or lactation (nursing); How long until maximum effect against fleas is reached; Other parasites killed, controlled or repelled; How often applied or administered
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Table 3:
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Oral or Topical, Prescription drug, non-prescription drug or insecticide; LD50 (lethal dose to 50% of the population)
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Table 4:
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Year first made available in U.S.; Manufacturer, Manufacturer’s website; Additional cautions
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TABLE 1
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Flea Killing
Ingredient
|
Flea Sterilizing or Additional Ingredients
|
For Dogs
or Cats
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Youngest Age or Size Approved For Use
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Waterproof or
Water Resistant?
|
|
Comfortis, AcuGuard*
|
Spinosad
|
none
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Dog
|
14 weeks; at least 5 lbs
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Waterproof
|
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Trifexis
|
Spinosad
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Milbemycin (for add’l parasites)
|
Dog
|
8 weeks; at least 5 lbs
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Waterproof
|
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Cheristin
|
Spinetoram
|
none
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Cat
|
8 weeks
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Water Resistant
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Credelio
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Lotilaner
|
none
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Dog
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8 weeks; at least 4.4 lbs
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Waterproof
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Credelio Feline
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Lotilaner
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None
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Cat
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At least 8 weeks and
at least 2 lbs for fleas
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Waterproof
|
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Vectra 3D, SimpleGuard 3*, FirstShield Trio*
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Dinotefuran & Permethrin
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Pyriproxifen (flea sterilizer)
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Dog
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7 weeks; at least 2.5 lbs
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Water Resistant
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Vectra for Cats, SimpleGuard for Cats*, FirstShield for Cats*
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Dinotefuran
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Pyriproxifen (flea sterilizer)
|
Cat
|
8 weeks
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Water Resistant
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Catego
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Dinotefuran & Fipronil
|
pyriproxifen
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Cat
|
1.5 lbs and 8 weeks
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Water Resistant
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Revolution, Paradyne, Revolt, Selarid
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Selamectin
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none
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Dog or Cat
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6 weeks puppies 8 weeks kittens
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Waterproof
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Revolution Plus
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Selamectin and
Saralaner
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none
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Cat
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8 weeks and 2.8 lbs
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Selamectin is waterproof, Suralaner is water resistant
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Advantage II, Combiva, Crossblock II, Paradefense for cats, Provecta for cats
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Imidacloprid
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Pyriproxifen (flea sterilizer)
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Dog or Cat
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7 weeks puppies 8 weeks kittens
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Waterproof
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K9Advantix II, Paradefense for dogs, Provecta for dogs, Imoxi
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Imidacloprid & Permethrin
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Pyriproxifen (flea sterilizer)
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Dog
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7 weeks, 4 lbs or larger
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Waterproof
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Advantage Multi also called Advocate, Imoxi Topical, Parasedge, Midamox, Barrier
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Imidacloprid
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Moxidectin (for additional parasites)
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Dog or Cat
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7 weeks puppies 9 weeks kittens
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Waterproof
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Advantus
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Imidocloprid
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none
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Dog
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10 weeks or older, 4 lbs or larger
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Waterproof
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Effitix
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Fipronil & Permethrin
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none
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Dog
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12 weeks
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Water Resistant
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Fiproguard, PetArmor, EasySpot (cats) Parastar (dogs) Effipro (cats)
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Fipronil
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none
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Dog or Cat
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8 weeks
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Waterproof
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Frontline Plus, Fiproguard Plus, PetArmor Plus, Ectoadvance Plus, Onguard Plus
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Fipronil
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Methoprene (flea sterilizer)
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Dog or Cat
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8 weeks
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Waterproof
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Frontline Gold
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Fipronil
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Methoprene, Pyriproxyfen
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Dog or Cat
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8 weeks and 5 lbs
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Waterproof but wait 24 hours before bathing or swimming
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Frontline Shield
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Fipronil
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Methoprene, Permethrin
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Dog Only
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9 weeks and 5 lbs
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Waterproof but wait 24 hours before bathing or swimming
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Activyl
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Indoxacarb
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Indoxacarb both kills and sterilizes fleas
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Dog or Cat
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puppies 8 weeks and 4 lbs, kittens 8 weeks and 2 lbs
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Waterproof (wait 24 hours before swimming/bathing)
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Activyl Tick Plus
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Indoxacarb & Permethrin
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Indoxacarb both kills and sterilizes fleas
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Dog
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8 weeks and 4 lbs
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Waterproof (wait 24 hours before swimming/bathing)
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Bravecto Chew
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Fluralaner
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none
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Dog
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6 months and 4 lbs
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Waterproof
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Bravecto Topical
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Fluralaner
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none
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Cat
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2.6 lbs, 6 months of age
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Water Resistant
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Bravecto Plus
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Fluralaner
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Moxidectin
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Cat
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2.6 lbs, 6 months of age
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Has not been evaluated
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Nexgard
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Afoxolaner
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none
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Dog
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8 weeks and 4 lbs
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Waterproof
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Simparica
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Sarolaner
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none
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Dog
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6 months and at least 2.8 lbs
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Waterproof
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Simparica Trio
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Sarolaner
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Moxidetin and Pyrantel pamoate
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Dog
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8 weeks, 2.8 lbs
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Waterproof
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Seresto
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Imidacloprid & Flumethrin
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none
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Dog or Cat but each has own product
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7 weeks old and 18 lbs for dogs,
10 weeks for kittens
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Water Resistant
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Program
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none
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Lufenuron (flea sterilizer)
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Dog or Cat
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4 weeks
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Waterproof
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Sentinel
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none
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Lufenuron (flea sterilizer) & Milbemycin (for add’l parasites)
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Dog
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4 weeks; at least 2 lbs
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Waterproof
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Capstar, Capguard, PetArmor FastCaps
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Nitenpyram
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none
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Dog or Cat
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4 weeks; at least 2 lbs
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Waterproof
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TABLE 2
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Approved for Pregnancy and Lactation (nursing)
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How Long Until Maximum Effect Against Fleas Is Reached?
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Other Parasites Killed, Controlled or Repelled
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How Often Applied
or Administered?
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Comfortis, AcuGuard*
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Manufacturer recommends against use but not specifically labeled against
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100% Fleas Dead in 4 Hours
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none
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Monthly
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Trifexis
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Manufacturer recommends against use but not specifically labeled against
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100% Fleas Dead in 4 Hours
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Hookworms, Roundworms, Whipworms & Heartworm
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Monthly
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Cheristin
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Manufacturer recommends consulting with veterinarian first
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98 - 100% Fleas Dead in 12 Hours
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none
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Monthly
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Credelio
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No
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Begins Killing Fleas in 4 hours,
99% Fleas Dead within 8 hours
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Demodectic Mange Mites, Ticks, Sarcoptic Mange Mites
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Monthly
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Credelio Feline
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No
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98% fleas killed in 12 hours, 100% in 24 hours, starts working within 6 hours
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Black Legged ticks (deer ticks)
in cats over 6 months of age
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Monthly
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Vectra 3D, SimpleGuard 3*, FirstShield Trio*
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No
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96% of Fleas Dead in 6 Hours
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Kills Ticks; Repels Flies and Mosquitos
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Monthly
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Vectra for Cats, SimpleGuard for Cats*, FirstShield for Cats*
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No
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98% of Fleas Dead in 6 Hours
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none
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Monthly
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Catego
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No
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98% fleas dead in 6 hours
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Kills Ticks & Lice
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Monthly
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Revolution, Paradyne, Revolt, Selarid
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Yes
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42 Hours to Zero Fleas
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Dogs: Ticks, Ear Mites, Sarcoptic Mange Mites & Heartworm Larvae
Cats: Hookworms, Roundworms, Ear Mites & Heartworm Larvae
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Monthly
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Revolution Plus
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No
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Greater than 98% of Pre-Existing Fleas Dead within 24 Hours; Then New Fleas Greater than 93.8% within 12 hours
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Ticks, Hookworms, Roundworms, Ear Mites, Heartworm
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Monthly
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Advantage II, Combiva, Crossblock II, Paradefense for cats, Provecta for cats
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Manufacturer recommends consulting with veterinarian first
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98% of Pre-Existing Fleas Dead in 12 Hours; Then New Fleas in 2 Hours
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none
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Monthly
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K9Advantix II, Paradefense for dogs, Provecta for dogs, Imoxi
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No
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98% of Fleas Dead in 12 Hours
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Kills Ticks; Repels Flies and Mosquitos
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Monthly
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Advantage Multi also called Advocate, Imoxi Topical, Parasedge, Midamox, Barrier
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No
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98% of Fleas Dead in 12 Hours
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Dogs: Whipworms, Hookworms, Roundworms & Heartworm
Cats: Hookworms, Roundworms, Ear Mites & Heartworm
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Monthly
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Advantus
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not tested for either situation
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96% fleas dead within 4 hours
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none
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daily or as needed (but not more than once a day)
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Effitix
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No
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90% of fleas dead in 6 hours, 99% in 12 hours
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Kills Ticks; Repels Mosquitos
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Monthly
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Fiproguard, PetArmor EasySpot (cats) Parastar (dogs) Effipro (cats)
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Topspot Yes; Spray No
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24 Hrs to Translocate, then 4-18 Hours to Kill Fleas
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Kills Ticks & Lice
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Monthly
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Frontline Plus, Fiproguard Plus, PetArmor Plus, Ectoadvance Plus, Onguard Plus
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Yes
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24 Hrs to Translocate, then 4-18 Hrs to Kill Fleas and 24-48 Hours to Kill Ticks
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Kills Ticks & Lice
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Monthly
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Frontline Gold
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Yes
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100% fleas dead in 12 hours
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Ticks, Chewing Lice
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Monthly
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Frontline Shield
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Manufacturer recommends consulting with veterinarian first
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100% fleas dead in 12 hours
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Ticks, Chewing Lice, repels mosquitos and stable flies
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Monthly
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Activyl
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no
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99.9% of fleas dead in 72 hours (66% of fleas dead in 24 hours)
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none
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6 weeks
(recommended to apply monthly)
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Activyl Tick Plus
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no
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99.9% of fleas dead in 72 hours (66% of fleas dead in 24 hours)
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Ticks
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4 weeks
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Bravecto Chew
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Yes
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88% in 4 hours, 100% in 12 hours
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Ticks, Sarcoptic Mange Mites, Demodectic Mange mites
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12 Weeks
(only kills Lone Star ticks for 8 weeks)
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Bravecto Topical
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no
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100% of fleas dead in 8 hours
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Deer Ticks, American Dog Ticks
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every 12 weeks for fleas
(every 8 weeks for ticks)
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Bravecto Plus
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no
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100% Flea kill within 12 hours
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Roundworms, Hookworms, two types of ticks, Heartworm, Ear mites
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Every 2 months
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Nexgard
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no
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99.5% fleas dead in 8 hours
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Kills Ticks
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Monthly
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Simparica
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no
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>96.2% of fleas dead within 8 hours, begins to kills fleas after 3 hours
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Kills Ticks, Kills Sarcoptic Mange Mites, kills ear mites
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Monthly
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Simparica Trio
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no
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100% fleas killed in 8 hours
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Kills Ticks, Sarcoptic Mange Mites, ear mites, roundworms, hookworms and heartworm
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Monthly
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Seresto
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no
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24 hours (after that new fleas killed within 2 hours)
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Ticks, Lice, aids in Sarcoptic Mange control
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8 months (5 months if pet swims
or bathes once a month or more),
30 days for lice
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Program
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Yes
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Peak activity at 6 Hours
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none
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Monthly for oral;
Every 6 Months for Injectable
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Sentinel
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Individual ingredients Yes, but combination not approved
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Peak activity at 6 Hours
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Hookworms, Roundworms, Whipworms & Heartworm
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Monthly
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Capstar, Capguard, PetArmor FastCaps
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Yes
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Maximum Effect in 4 Hours
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none
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As Needed or Daily
(no lasting activity)
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TABLE 3
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Oral or Topical?
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Prescription Drug, Non-Prescription Drug or Insectcide
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Lethal Dose to 50% of the Population
(the higher the number, the safer the product)
[What is LD50?]
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Comfortis, AcuGuard*
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Oral (Chewable)
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Prescription Drug
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>3,000 mg/kg in rats; >2.000 mg/kg in rabbits (translates to over 30 times recommended dose)
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Trifexis
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Oral (Chewable)
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Prescription Drug
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Spinosad: >3,000 mg/kg in rats; >2.000 mg/kg in rabbits Milbemycin LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
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Cheristin
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Topical
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Insecticide
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Dermal and Oral LD50 in rats > 5,000 mg/kg
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Credelio
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Oral
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Prescription Drug
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>2000 mg/kg in rats
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Credelio Feline
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Oral
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Prescription Drug
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>2000 mg/kg in rats
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Vectra 3D, SimpleGuard 3*, FirstShield Trio*
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Topical
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Insecticide
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>2,400 mg/kg in rats for Dinotefuran, >4,000 mg/kg in rats for topical Permethrin
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Vectra for Cats, SimpleGuard for Cats*, FirstShield for Cats*
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Topical
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Insecticide
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>2,400 mg/kg in rats for Dinotefuran
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Catego
|
Topical
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Insecticide
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Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats; >2,400 mg/kg in rats for Dinotefuran
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Revolution, Paradyne, Revolt, Selarid
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Applied Topically, but rapidly absorbed through skin
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Prescription Drug
|
>1,600 mg/kg in rats
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Revolution Plus
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Topical
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Prescription Drug
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Selamectin: >1,600 mg/kg in rats. Sarolaner: LD50 in rats, for skin exposure is >2020 mg/kg. Product doses are typically <100mg per dose.
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Advantage II, Combiva, Crossblock II, Paradefense for cats, Provecta for cats
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Topical
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Insecticide
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Dermal Dose: >5,000 mg/kg in rats Orally: 450 mg/kg in rats
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K9Advantix II, Paradefense for dogs, Provecta for dogs, Imoxi
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Topical
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Insecticide
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Imidacloprid Dermal Dose: >5,000 mg/kg in rats Imidacloprid Orally: 450 mg/kg in rats >4,000 mg/kg in rats for Permethrin
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Advantage Multi also called Advocate, Imoxi Topical, Parasedge, Midamox, Barrier
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Topical
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Prescription Drug
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Imidacloprid Dermal Dose: >5,000 mg/kg in rats Imidacloprid Orally: 450 mg/kg in rats >2,000 mg/kg in rabbits for Moxidectin
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Advantus
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Oral
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Over the Counter Drug
|
450 mg/kg in rats
|
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Effitix
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Topical
|
Insecticide
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Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats; >4,000 mg/kg in rats for topical Permethrin
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Fiproguard, PetArmor EasySpot (cats) Parastar (dogs) Effipro (cats)
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Topical Topspot or Spray
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Insecticide
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Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats
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Frontline Plus, Fiproguard Plus, PetArmor Plus, Ectoadvance Plus, Onguard Plus
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Topical
|
Insecticide
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Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats Methoprene Orally: >34,600 in rats (virtually non-toxic)
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Frontline Gold
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Topical
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Insecticide
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Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats Methoprene Orally: >34,600 in rats (virtually non-toxic)
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Frontline Shield
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Topical
|
Insecticide
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Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats Methoprene Orally: >34,600 in rats (virtually non-toxic)
>4,000 mg/kg in rats for Permethrin
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Activyl
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Topical
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Insecticide
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Indoxacarb must be activated by insect metabolism (no activity in mammals)
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Activyl Tick Plus
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Topical
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Insecticide
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Indoxacarb is inert in the mammal body, >4,000 mg/kg in rats for Permethrin
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Bravecto Chew
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Oral
|
Prescription Drug
|
Dermal LD50: >2000 mg/kg (rat), Oral LD50: >2000 mg/kg (rat)
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Bravecto Topical
|
Topical
|
Prescription Drug
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Dermal LD50: >2000 mg/kg (rat), Oral LD50: >2000 mg/kg (rat)
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Bravecto Plus
|
Topical
|
Prescription Drug
|
Fluralaner: Dermal LD50: >2000 mg/kg (rat), Oral LD50: >2000 mg/kg (rat)
Moxidectin: 106 mg/kg orally
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Nexgard
|
Oral
|
Prescription Drug
|
LD50: > 1000 mg/kg in rats
|
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Simparica
|
Oral (flavored chewable)
|
Prescription Drug
|
approx 783 mg/kg in the rat (over 300 times the therapeutic dose in the dog)
|
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Simparica Trio
|
Oral
|
Prescription Drug
|
approx 783 mg/kg in the rat (over 300 times the therapeutic dose in the dog)
|
|
Seresto
|
Neither, it's a collar
|
Insecticide
|
imidacloprid dermal dose: >5,000 mg/kg in rats
Imidacloprid orally: 450 mg/kg in rats, flumethrin: ld50 oral rat (male) 258 mg/kg, ld50 dermal rat > 150 mg/kg
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Program
|
Oral; or Injectable for Cats only
|
Over the Counter Drug
|
Orally: > 2,000 mg/kg in rats
|
|
Sentinel
|
Oral
|
Prescription Drug
|
Lufenuron Orally: > 2,000 mg/kg in rats Milbemycin LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
|
|
Capstar, Capguard, PetArmor FastCaps
|
Oral
|
Over the Counter Drug
|
Orally: 1,575 mg/kg in rats
|
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TABLE 4
|
Year First Made
Available in U.S.
|
Manufacturer
|
Manufacturer Website
|
Additional Cautions
|
|
Comfortis, AcuGuard*
|
2007
|
Elanco
|
www.comfortis4dogs.com (AcuGuard is a private label*)
|
May promote seizures in dogs already predisposed to seizures
|
|
Trifexis
|
2011
|
Elanco
|
www.trifexis.com
|
Puppies less than 14 weeks of age may experience a higher rate of vomiting. May promote seizures in dogs already predisposed to seizures
|
|
Cheristin
|
2011
|
Elanco
|
www.cheristin4cats.com
|
none
|
|
Credelio
|
2018
|
Elanco
|
www.credelio.com
|
History of seizures, must give with food. Adverse reactions can include: lethargy, tremors, appetite loss, seizures.
|
|
Credelio Feline
|
2021
|
Elanco
|
www.credelio.com
|
History of seizures, must give with food. Adverse reactions can include: lethargy, tremors, appetite loss, seizures.
|
|
Vectra 3D, SimpleGuard 3*, FirstShield Trio*
|
2007
|
Ceva
|
www.vectrapet.com
(SimpleGuard 3 and FirstShield Trio are private labels*)
|
none
|
|
Vectra for Cats, SimpleGuard for Cats*, FirstShield for Cats*
|
2008
|
Ceva
|
www.vectrapet.com
(SimpleGuard 3 and FirstShield Trio are private labels*)
|
none
|
|
Catego
|
2017
|
Ceva
|
www.categocat.com
|
none
|
|
Revolution, Paradyne, Revolt
|
2000
|
Zoetis
|
www.zoetisus.com/products/pages/revolution_pet/revolutionpet.aspx
http://vethical.com/cats/paradyne
|
Pets should test negative for Heartworm before use
|
|
Revolution Plus
|
2019
|
Zoetis
|
www.zoetisus.com/products/cats/revolution-plus/index.aspx
|
Caution in cats with concurrent neurologic disease, adverse reactions can rarely include: lethargy, tremors, appetite loss, seizures. Wash hands after using product, as it is irritating to your eyes.
|
|
Advantage II, Combiva, Crossblock II, Paradefense for cats, Provecta for cats
|
1996
|
Bayer
|
http://advantage.petparents.com
www.paradefensepet.com/consumer-cat
|
none
|
|
K9Advantix II, Paradefense for dogs, Provecta for dogs, Imoxi
|
2003
|
Bayer
|
http://k9advantix.petparents.com
www.paradefensepet.com
https://provectapet.com
|
Do not use in cats (cats are sensitive to Permethrin)
|
|
Advantage Multi also called Advocate, Imoxi Topical, Parasedge, Midamox, Barrier
|
2007
|
Bayer
|
http://advantagemulti.petparents.com
|
Pets should test negative for Heartworm before use
|
|
Advantus
|
2017
|
Bayer
|
www.petbasics.com/dog-products/advantus/product-detail
|
none
|
|
Effitix
|
2012
|
Virbac
|
www.virbacvet.com
|
Canine product cannot be safely used on cats
|
|
Fiproguard, PetArmor EasySpot (cats) Parastar (dogs) Effipro (cats)
|
1996 (Frontline)
2012 (Effipro)
2011 (all others)
|
Merial Sentry FidoPharm
|
www.frontline.com www.sentrypetcare.com www.petarmor.com www.easyspotpet.com www.parastarpet.com www.virbacvet.com
|
none
|
|
Frontline Plus, Fiproguard Plus, PetArmor Plus, Ectoadvance Plus, Onguard Plus
|
2000
|
Merial Sentry FidoPharm
|
www.frontline.com www.sentrypetcare.com
www.petarmor.com www.ectoadvanceplus.com
|
none
|
|
Frontline Gold
|
2016
|
Merial
|
www.frontline.com
|
none
|
|
Frontline Shield
|
2020
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Merial
|
www.frontline.com
|
Toxic to cats
|
|
Activyl
|
2012
|
Merck Animal Health
|
www.activyl.com
|
Fleas tend to get more active when this product works on them so tend to be more visible. It may look like the pet has more fleas.
|
|
Activyl Tick Plus
|
2012
|
Merck Animal Health
|
www.activyl.com
|
Toxic to cats
|
|
Bravecto Chew
|
2014
|
Merck Animal Health
|
bravecto.com
|
Adverse reactions can include: lethargy, tremors, appetite loss, seizures.
|
|
Bravecto Topical
|
2016
|
Merck Animal Health
|
bravecto.com
|
Adverse reactions can include: lethargy, tremors, appetite loss, seizures.
|
|
Bravecto Plus
|
2020
|
Merck Animal Health
|
us.bravecto.com/plus-for-cats
|
Caution in cats with concurrent neurologic disease, adverse reactions can rarely include: lethargy, tremors, appetite loss, seizures. Wash hands after using product, as it is irritating to your eyes.
|
|
Nexgard
|
2014
|
Merial
|
www.nexgardfordogs.com
|
May promote seizures in dogs already predisposed to seizures. Adverse reactions can include: lethargy, tremors, appetite loss.
|
|
Simparica
|
2016
|
Zoetis
|
www.zoetispetcare.com/products/simparica
|
Should not be used in dogs with known seizure disorders, wash hands after using product. Adverse reactions can include: lethargy, tremors, appetite loss.
|
|
Simparica Trio
|
2022
|
Zoetis
|
www.zoetispetcare.com/products/simparica-trio
|
Should not be used in dogs with known seizure disorders, wash hands after using product. Adverse reactions can include: lethargy, tremors, appetite loss.
|
|
Seresto
|
2012
|
Bayer
|
www.petparents.com/products.aspx/index/seresto
|
Safety features of collar present so that collar breaks off if caught
|
|
Program
|
1994
|
Novartis
|
www.program.novartis.us
|
Give with food
|
|
Sentinel
|
1997
|
Novartis
|
www.sentinel.novartis.us
|
Give with food; Pets should test negative for Heartworm before use
|
|
Capstar, Capguard, PetArmor FastCaps
|
2000
|
Novartis
|
www.drugs.com/pro/capstar.html
|
none
|
As of spring 2011, Pfizer has discontinued the manufacture of Promeris (active ingredients: amitraz and metaflumizone)
As of 2016, Merial stopped production of Frontline Tritak. (active ingredients: fipronil, cyphenothrin or etophenprox, methoprene)
* VCA Animal Hospitals and Banfield Pet Hospitals market some products under their own hospital private label, made by the
same manufacterer as the original product. It is the same product (made by the same manufacturer) but with a different name.
Page last updated: 2/7/2024
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