Heartworm Preventive Comparison

Confused about Heartworm prevention options? These two charts compare current heartworm preventive products side by side to assist you in determining which is right for your situation.

 

For
Dogs or Cats

Heartworm Preventing Ingredient

Other Ingredients for Control of Other Parasites

Other Parasites Controlled

Mode of Application

Youngest Age to Start Using

Heartgard
for Dogs

Dogs

Ivermectin

None

None

oral

6 weeks

Heartgard Plus
Iverhart Plus
Iverhart Max
Triheart Plus
Pet Trust Plus

Dogs

Ivermectin

Pyrantel
Pamoate

Iverhart Max also
has Praziquantel

Hookworms, Roundworms
Iverhart Max also covers Tapeworms

oral

6 weeks

Heartgard
for Cats

Cats

Ivermectin

None

Hookworms

oral

6 weeks

Interceptor

Dogs
and Cats

Milbemycin Oxime

None

Hookworms, Roundworms, Whipworms

oral

4 weeks
for puppies
6 weeks
for kittens

Sentinel
Sentinel Spectrum

Dogs

Milbemycin Oxime

Lufenuron
Sentinel Spectrum also has Praziquantel

Hookworms, Roundworms, Whipworms, sterilizes Fleas
Sentinel Spectrum also covers Tapeworms

oral

4 weeks

Revolution

Dogs
and Cats

Selamectin

None

For dogs: Fleas, Ticks, Ear Mites, Sarcoptic Mange Mites
For Cats: Fleas, Ear Mites, Hookworms, Roundworms

topical

6 weeks
for puppies
8 weeks
for kittens

Advantage Multi

Dogs
and Cats

Moxidectin

Imidocloprid

For dogs: Fleas, Hookworms, Roundworms, Whipworms
For Cats: Fleas, Ear Mites, Hookworms, Roundworms

topical

7 weeks
for puppies
9 weeks
for kittens

Proheart6

Dogs

Moxidectin

None

Hookworms

injectable

6 months
(and no older than 7 years)

Trifexis

Dogs

Milbemycin Oxime

Spinosad

Fleas, Hookworms, Roundworms, Whipworms

oral

8 weeks

 

 

How Often Used

Approved for Pregnancy and Lactation?

Water-proof?

Safe to Give to Heartworm Positive Animal?

Manufacturer Website

LD50
what’s this?

Heartgard
for Dogs

monthly

yes

yes

yes

Heartgard

10 mg/kg in rats orally according to MSDS sheet for Parade Equine Gel

Heartgard Plus
Iverhart Plus
Triheart Plus
Pet Trust Plus

monthly

yes

yes

yes

Heartgard Plus
Iverhart Plus
Triheart Plus
PetTrustPlus

10 mg/kg in rats orally for ivermectin; >690 mg/kg in dogs orally for Pyrantel Pamoate according to The Elephant Formulary by Mikota and Plumb

Heartgard
for Cats

monthly

yes

yes

yes

Heartgard

10 mg/kg in rats orally

Interceptor

monthly

yes

yes

In most cases yes but if microfilariae numbers are high then no

Interceptor

LD50 information unavailable

Symptoms of tremors and incoordination result at 19 times recommended dose

Sentinel
Sentinel Spectrum

monthly

yes

yes

In most cases yes but if microfilariae numbers are high then no

Sentinel

LD50 information unavailable

Symptoms of tremors and incoordination result at 19 times recommended dose

Revolution

monthly

yes

yes

yes

Revolution

>1600 mg/kg in the rat orally

Advantage Multi

monthly

no

no

yes

Advantage
Multi

Moxidectin: 106 mg/kg orally;
Imidocloprid: 450 mg/kg in the rat orally

Proheart6

every 6 months

yes

yes

No, in fact owner must agree to
pre-treatment labwork including heartworm testing

Proheart6

263 mg/kg in the rat when given by injection (the dose used therapeutically is 0.17mg/kg)

Trifexis

monthly

Manufactuer cautions use, says to discuss with your veterinarian

yes

In most cases yes but if microfilariae numbers are high then no

Trifexis

Milbemycin Oxime: LD50 information unavailable  Spinosad: >3,000 mg/kg in rats; >2,000 mg/kg in rabbits (translates to over 30 times recommended dose)

 

For a comparison of the anti-flea products
(Comfortis, Vectra 3D, Vectra for Cats, Promeris, Promeris Feline,
Revolution, Advantage, K9 Advantix, Advantage Multi,
Frontline, Frontline Plus, Program, Sentinel and Capstar),
click here.

For comparison of the anti-tick products
(K9 Advantix, Revolution, Promeris, Preventic Collar, Frontline and Vectra 3D)
click here.

Page last updated: 3/28/2012