American Dog Tick, Vector of: Rocky Mountain Spotted Fever Brown Dog Tick, Vector of: Ehrlichiosis Lone Star Tick (note the "star" on the belly), Vector of: Rocky Mountain Spotted Fever Deer Tick or Black-legged tick, Vector of: Lyme disease (Borrelia burgdorferi), and Anaplasmosis (Anaplasma platys)

	K9Advantix	Revolution	Promeris	Preventic Collar	Frontline	Vectra 3D
Tick Killing Ingredient	Permethrin	Selamectin	Amitraz	Amitraz	Fipronil	Permethrin
Format	Topical	Topical	Topical	Collar	Topical or spray	Topical
For dogs or cats?	Dogs only	Feline product available but not labeled against ticks	Dogs only (feline product does not include a tick ingredient)	Dogs only	Dogs and Cats	Dogs only (feline product does not include a tick ingredient)
Approved against which ticks	all shown above	American Dog Tick only	all shown above	all shown above	all shown above	all shown above
Youngest Age Approved	7 weeks	6 weeks	8 weeks	12 weeks	8 weeks	7 weeks and 2.5 lbs
How long One Application Lasts	1 month	1 month	6 weeks	up to 90 days	1 month	1 month
Waterproof or water resistant?	water resistant	water proof	water proof	water resistant (remove collar for bathing)	water proof	water resistant
Approved for Pregnancy and Lactation?	No	Yes	No	Not specifically labeled against, veterinary consultation recommended.	Yes for topspot, no for spray	No
Time to Reach Maximum Effect	98% dead within 48 hours	48 hours	99% dead within 24 hours, 100% dead in 48 hours	100% dead in less than 24 hours	24 - 48 hours	98% dead within 48 hours
Other parasites controlled or repelled:	fleas, flies, mosquitoes	ear mites, fleas, sarcoptic mange mites, heartworm	fleas	none	fleas	fleas, flies, mosquitoes
Other active ingredients:	imidocloprid	none	metaflumizone	none	methoprene in Frontline PLUS	dinotefuran, pyriproxifen (former kills fleas, latter sterilizes them until former product kills them)
Prescription Drug or Insecticide?	insecticide	prescription drug	insecticide	insecticide	insecticide	insecticide
Toxicity/LD 50 (what is LD 50?)	Imidacloprid Dermal Dose: >5,000 mg/kg in rats Imidacloprid Orally: 450 mg/kg in rats >4,000 mg/kg in rats for Permethrin	>1,600 mg/kg in rats	>5,000 mg/kg in rats for Metaflumizone, > 2,000 mg/kg in rats for Amitraz	> 2,000 mg/kg in rats for Amitraz	Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats Methoprene Orally: >34,600 in rats (virtually non-toxic)	>2,400 mg/kg in rats for Dinotefuran, >4,000 mg/kg in rats for topical Permethrin
Manufacturer and product web site	Bayer	Pfizer	Fort Dodge	Virbac	Merial	Summit
Additional Cautions	Permethrin is toxic to cats, use feline product only for cats. Avoid cat/dog snuggling.	Dog should test negative for heartworm before using	Amitraz is associated with an assortment of drug interactions, check with your vet.	Amitraz is associated with an assortment of drug interactions, check with your vet. Also, collar is toxic if swallowed.	none	Permethrin is toxic to cats, use feline product only for cats. Avoid cat/dog snuggling.

For general tick information including how to remove ticks, U.S. maps showing prevalence of tick-borne disease, and other general information, please visit:     www.dogsandticks.com