(for veterinary information only)
BRAND NAME: ZENIQUIN
Human beings have been at odds with microbes since the beginning of time and the quest for new medications continues even today. When sulfa drugs came on the scene in the 1940's, an "age of antibiotics" was born and a new dimension had opened in the combat against microbes. From there a proliferation of antibiotics developed, each new medication exploiting a different aspect of bacterial metabolism until it seemed that the war on microbes would soon be won.
Despite this progress, one particular bacterial species remained seemingly invincible: Pseudomonas aeruginosa. This species of bacteria was able to change its antibiotic susceptibility with each antibiotic exposure, become resistant to multiple drugs in response to every medication used against it. Eventually, the aminoglycoside class of antibiotics was developed and there was finally a way to kill Pseudomonas fairly reliably but the price was that medication was injectable only, necessitating hospitalization for the patient, and potential kidney damage could result with prolonged use.
Fluoroquinolones work by deactivating bacterial enzymes necessary for the transcription of DNA. DNA is very tightly coiled in order to fit inside a cell. Segments to be used must be uncoiled by an enzyme called DNA gyrase. The fluoroquinolone antibiotic deactivates DNA gyrase making the reading of DNA impossible. The bacterial cell dies. Mammalian DNA gyrase is of a completely different shape and remains unharmed.
USES OF THIS MEDICATION
This medication may be used in either dogs or cats to combat different types of infections, especially those involving Pseudomonas and/or other Gram negative bacteria. Marbofloxacin is also active against Staphylococci, and thus is commonly used for skin infections.
As with most oral medications, the most common side effects of marbofloxacin are related to the GI tract: vomiting, diarrhea, reduced appetite.
In immature dogs (less than 8 months of age for medium dogs, less than 12 months of age for large breeds, less than 18 months for giant breeds) damage to developing joint cartilage can occur. This phenomenon is only seen in growing dogs and does not seem to be a problem in cats. It is preferable not to use this medication in puppies unless the severity of the infection present warrants it.
Enrofloxacin, the first veterinary fluoroquinolone, was found to lead to retinal damage and blindness when used in higher doses in cats. This is because the feline retina has a tendency to accumulate enrofloxacin. Marbofloxacin was developed to have less affinity for the feline retina but it is unknown if this problem still occurs in higher doses.
Fluoroquinolone antibiotics may lower the seizure threshold and increase a patient's tendency to have seizures. This is of no concern in a normal animal but is worth a cautionary statement for patients with a pre-existing seizure disorder.
INTERACTIONS WITH OTHER DRUGS
Sucralfate (a medication used to treat stomach ulcers) may bind marbofloxacin and prevent it from entering the body. These medications should be given at least 2 hours apart if they are used together. A similar phenomenon occurs with magnesium and calcium-containing antacids.
Theophylline (an airway dilator) blood levels may be higher than usual if this medication is used concurrently with marbofloxacin. The dose of theophylline may need to be reduced.
If marbofloxacin is used with oral cyclosporine (an immunosuppressive medication used for inflammatory bowel disease), the kidney damaging properties of cyclosporine may become worse.
Medications or supplements containing iron, zinc, magnesium or aluminum will bind enrofloxacin and prevent absorption into the body. Such medications should be separated from marbofloxacin by at least 2 hours.
CONCERNS AND CAUTIONS
Pseudomonas infections are especially common in canine ears. In this location, especially higher doses of marbofloxacin are needed to clear this infection. Expect expense as this is a unique antibiotic and at this time there is no comparable generic.
Marbofloxacin should not be used in pregnant, or nursing pets or in immature dogs unless the severity of the infection warrants it.
Page posted: 4/29/2013