The “pemphigus complex” is a group immune-mediated skin diseases involving inappropriate immunological attack against one of the normal layers of the skin. Different types of pemphigus involves different areas of the skin.
OOPS , YOUR EPIDERMIS IS SHOWING
The outer layer of the skin is called the “epidermis” and consists of cells arranged in layers. Living new cells are at the bottom and dead cells are at the top, exposed to the outside world where they are constantly brushing off. The cells that make up the skin are keratinocytes (what we think of as skin cells), melanocytes (which produce pigment and give us a sun tan), Langerhans’ cells (part of the immune system), and Merkel cells (“mechanoreceptors” which let the nervous system know we are being touched).
Drawing showing the different layers of the epidermis (skin)
Let’s look at the layers of normal skin starting at the bottom:
Basal Layer (or “stratum basale”)
Spinous Layer (or “prickle cell layer” or “stratum spinosum”)
Granular Layer (or “stratum granulosum”)
Clear Layer (or “stratum lucidum”)
Horny Layer (or “stratum corneum”)
BACK TO THE PEMPHIGUS COMPLEX
The pemphigus skin diseases involve immunological attack of the attachment of skin cells to one another.
PEMPHIGUS VULGARIS – The attachment of the basal cell layer and prickle cell layer is attacked forming fluid filled blisters called “vesicles.” These easily rupture leaving painful ulcerative lesions.
PEMPHIGUS ERYTHEMATOSUS - The attachment of the stratum corneum is attacked.
BULLOUS PEMPHIGOID – The attachment of the whole epidermis to the dermis is attacked.
PEMPHIGUS FOLIACEUS – The attachment of the granular cells to one another is attacked. Pemphigus foliaceus is the most common immune-mediated skin disease of the dog and cat. The separation of granular cells creates crusts and ulcers generally around the eyes, ears, footpads, groin, and bridge of the nose. In cats, lesions also orient at the toenail beds creating crusty sore feet. The Akita seems to be particularly predisposed to the development of this condition. Pemphigus foliaceus is usually spontaneous but can also be drug induced or can result as a reaction to years of chronic skin disease.
(original graphics by marvistavet.com)
Max after 4 months of treatment
(original graphics by marvistavet.com)
The treatment for pemphigus foliaceus is immune-suppression. In about 50% of patients this is achieved with high doses of corticosteroids (either prednisone or dexamethasone). Secondary infections are common and antibiotic therapy is required. Special anti-bacterial baths may also help.
Side effects from high doses of steroid hormones are to be expected. The patient will drink excessively, urinate excessively, be very hungry, and gain weight. Dogs will pant a lot and cats run the risk of developing diabetes mellitus if they are on high doses long enough. Incontinence from all the water consumption can be problematic. Mobility issues from obesity can also result.
For dogs that cannot tolerate steroids at doses high enough to control the pemphigus symptoms (or for whom steroids alone are unable to control symptoms), azathioprine, a stronger immune-suppressant, is generally added. It should be realized that it can take up to 2 months for azathioprine to exert a significant effect and the corticosteroid is needed during this time. Azathioprine has potential to cause bone marrow suppression and blood testing is needed every 2 weeks during initial treatment, though this interval can be tapered as the patient becomes more stable. For cats who do not tolerate or respond to corticosteroids alone, chlorambucil is similarly recommended with similar monitoring. Cyclosporine is still being explored as a treatment for use in this condition. It appears to be helpful in cats but not dogs.
Expense and side effects can be very taxing for a pet owning family and in one retrospective study of 43 dogs with pemphigus foliaceus a 60% mortality rate was observed, largely reflecting euthanasia.
Treatment for this condition is gradually withdrawn after the lesions are cleared up and the patient is stable. Many dogs ultimately discontinue all treatment permanently but this is after many months. It is important not to be discouraged by failure to achieve a rapid response; this condition requires time and patience.
For information on long term side effects of corticosteroid use click here.
Page last updated: 2/11/2011