WHAT IS THE TRACHEA ANYWAY?
“Trachea” is the scientific name for the windpipe, the tube that connects the nose, mouth, and throat to the lungs. The trachea is meant to be a fairly rigid tube. It consists of muscle connecting a group of cartilage rings. The rings are actually not complete circles; they form a C with the open end of the C facing towards the animal's back. This muscle covering the open end of the C is called the “tracheal membrane”.
When the diaphragm (the flat muscle separating the abdomen from the chest cavity) flattens and the intercostal muscles (the muscles between the ribs) move, air is sucked into the lung. When the muscles move the opposite direction, air is pushed out of the lung. The trachea serves as a pipeline bringing air into the chest. Part of the trachea is in the throat but it also extends into the chest so that we can look at the trachea as having an intrathoracic portion (inside the chest) and an extrathoracic portion (outside the chest).
WHY WOULD A TRACHEA COLLAPSE?
Tracheas collapse because the cartilage rings weaken. When the C loses its curvature, the tracheal membrane across the gets loose and floppy. Instead of being a tight muscle canopy, the now flimsy membrane moves as air passes through the trachea. When air rushes into the chest, the membrane of the intrathoracic trachea balloons outward and when air rushes out, the membrane of the intrathoracic trachea droops down into the C cartilage causing an occlusion. The tickling sensation of the membrane touching the tracheal lining generates coughing and if the obstruction interrupts breathing, the patient may become distressed. If the collapse is in the extrathoracic (also called the cervical) trachea, the opposite occurs; the collapse occurs during inhalation and the ballooning during exhalation.
x-ray of patient with collapsed trachea inhaling
same patient exhaling
Panting or rapid breathing for any reason makes the collapse and anxiety worse, which unfortunately tends to generate more rapid breathing and a vicious cycle of distress.
Making things worse still is the inflammation generated in the trachea. The collapse creates increased secretion and inflammation thus promoting yet more coughing which creates yet more inflammation. Ultimately, the tissue of the trachea changes and loses its normal characteristics and the condition gets worse and worse.
The trachea may be collapsed along its entire length, only in the intrathoracic section, or only in the extrathoracic section. Most commonly the collapse is at its worse right where the trachea enters the chest.
Same patient as above, a year later
WHAT ANIMALS ARE AFFECTED?
The victim is almost always a toy breed dog, with poodles, Yorkshire terriers, and Pomeranians most commonly affected. The disease usually becomes problematic in middle age but can occur at any age. The cartilage defect that leads to the flattened C rings seems to be hereditary.
Many dogs with collapsed tracheas do not show symptoms, however, until a second problem complicates matters. Factors that bring out symptoms might include:
If a secondary factor such as one of those listed above should occur and make a previously incidental collapsed trachea a problem, often removal of the secondary factor (weight loss program, getting an air filter, etc.) may clear up the symptoms of the collapsed trachea.
The following steps are often helpful in long-term management of the tracheal collapse patient:
In a recent retrospective study of 100 dogs with collapsing trachea, 71% responded to medication and management of secondary factors (obesity, irritants in the air, etc.), 7% had disease so severe that they died within one month of diagnosis, 6% had severe additional disease problems, and the other 16% were felt to be candidates for surgical treatment (see below).
The patient's distress can reach a level so severe that the normally pink mucous membranes become bluish and collapse can result. When this occurs, tranquilization is helpful to relieve the anxiety that perpetuates the heavy breathing and coughing. Oxygen therapy and cough suppressants also help. If the patient reaches the point where distress seems extreme or if collapse results, treat this an emergency and rush the pet to emergency veterinary care.
If medical management does not produce satisfactory results, it is possible that surgery may be of benefit. Basically, a rigid prosthesis is placed and bonded around the trachea effectively creating a non-collapsible tube. This is largely effective as long as the portion of trachea that is collapsed is external to the chest. Should the intrathoracic trachea be involved, the surgery becomes far less successful, more expensive, and the prosthesis must be ordered according to the specific patient’s measurements.
In all surgery cases, the younger the patient, the more successful the surgery is likely to be with success dropping off in patients over age 6 years. Severity of the collapse prior to surgery is not a tremendous factor in obtaining a successful outcome; improvement is reported in 75% to 85% of patients.
A new technique is being explored using a self-expanding stainless steel prosthesis. A study reporting results of 24 dogs receiving this treatment was published in January 2004. Of these dogs, 96% showed improvement after surgery. Two dogs died within the first week due to stent placement complications. One dog experienced some bleeding. After this 30% were reported to be completely free of symptoms, 61% showed marked improvement, and 4% continued to have symptoms. This appears to be a promising technique but has still only been used in a small number of patients.
Radiograph of a dog with tracheal stent in place
Surgical therapy of tracheal collapse requires a surgery specialist. If one is not on staff or cannot be scheduled, referral can be arranged. For more information on this procedure, the American College of Veterinary Surgeons has a web page at:
IS THERE ASSOCIATED LIVER DISEASE?
In the July/August 2006 issue of the Journal of Veterinary Internal Medicine, a group of researchers led by Natali B. Bauer pursued the common finding of enlarged liver in dogs with tracheal collapse. Her group looked at 26 dogs with tracheal collapse and compared liver function test results to 42 dogs without tracheal collapse. Ninety-two percent (92%) of dogs with tracheal collapse were found to have abnormal results. Dogs that received stent placement to assist their breathing showed improvement in these tests. It was concluded that oxygen deprivation from the collapse had resulted in significant liver disease in many tracheal collapse patients. It was further recommended that tracheal collapse patients have liver function tests periodically performed as liver supportive medications may be helpful.
Page last updated: 5/7/09