(for veterinary information only)
BRAND NAME: AZULFIDINE, SULFAZINE
Colitis is another word for “inflammation of the colon (large intestine)". Clinical signs include bloody or mucous diarrhea with urgency and sometimes vomiting. Since the colon is the very last portion of the intestinal tract (following the mouth, esophagus, stomach, and small intestine), medications must reach the colon in one of two ways. They must either resist digestion all the way down until they get to their final destination in the colon or they must be absorbed into the body earlier in the digestion, enter the bloodstream and reach the colon through its blood supply. Sulfasalazine utilizes the former mechanism.
Sulfasalazine is created by bonding a sulfa antibiotic called “sulfapyridine” to a salt of salicylic acid (aspirin). The bond is intact all the way down the intestinal tract until it is cleaved in the colon by resident bacteria releasing the two component molecules. The sulfa antibiotic is absorbed into the body and has minimal effect but the salicylic acid exerts its famous anti-inflammatory effects locally. Essentially a salve is applied to the surface of the inflamed colon.
HOW THIS MEDICATION IS USED
Sulfasalazine is given as a tablet three times daily, which makes it somewhat less convenient to use than other medications commonly used for colitis (metronidazole, tylosin). It is usually not given for courses longer than 3 weeks due possible side effects on tear production (see below).
Sulfa type antibiotics have been associated with several rare but well documented side effect syndromes:
It should be noted that the above side effects are a list of the classical side effects reported with sulfa antibiotics in general; they do not refer to sulfasalazine specifically. The sulfa moiety of sulfasalazine demonstrates side effects only rarely with tear production problems being the only one of any likelihood. The others are potential side effects as they have been seen with closely related drugs.
INTERACTIONS WITH OTHER DRUGS
The sulfa moiety of sulfasalazine, once absorbed into the body, is quickly bound to a protein carrier (i.e. once inside the body, it travels through the circulation coupled with blood proteins.) If the patient is concurrently taking other drugs that rely on protein carriers to travel in the circulation, the sulfa may “bump” these other drugs off the carrier. Once a drug is “bumped” off the carrier, it is able to act on its target tissue. This means that protein-bound drugs are stronger in patients concurrently taking sulfas. Drugs which may be enhanced in this way include: methotrexate (a cancer chemotherapy agent), warfarin (an anti-coagulant used both therapeutically and as the active ingredient in rat poisons), thiazide diuretics, aspirin, and phenytoin (an anti-seizure drug).
Digoxin (a heart medication), may work less effectively in the presence of sulfasalazine.
CONCERNS AND CAUTIONS
Cats are sensitive to salicylates. This medication is used in dogs or with dosage adjustments for cats.
This drug may effect male fertility.
When sulfasalazine has been given to pregnant women, birth defects have occasionally arisen. It is best not to use this medication during pregnancy.
It has been noted that the only side effect of
Sulfasalazine is a brightly orange colored medication.
Page last updated: 1/17/2017