(for veterinary information only)
BRAND NAME: RECONCILE, PROZAC
HOW THIS MEDICATION IS USED
It should be noted that the treatment of behavior disorders requires training in addition to medication. When medication and behavior modification were combined, 42% of dogs with separation anxiety showed improvement by the end of the first week and 73% were improved within 8 weeks. These statistics were obtained using the B.O.N.D. training program designed for use with brand name Reconcile®. For more information, visit Reconcile.com. Obviously, there are a number of training techniques for use in the management of separation anxiety; the point is that best results are obtained when fluoxetine is combined with training.
Fluoxetine is usually given once daily, with or without food. If a dose is accidentally skipped, do not double up on the next dose but instead, give the next dose when it is rememberd and time the following dose accordingly.
Fluoxetine should not be discontinued abruptly. If you wish to discontinue this medication, ask your veterinarian for a tapering schedule.
Fluoxetine should be stored at room temperature away from light.
COMMON SIDE EFFECTS WHICH ARE GENERALLY NOT SERIOUS:
SIDE EFFECTS THAT ARE LESS COMMON BUT MORE SERIOUS:
INTERACTIONS WITH OTHER DRUGS
Serotonin syndrome is a potentially dangerous situation that can result when serotonin levels get too high. Elevated heart rate, tremors/shivering, dilated pupils, difficulty breathing, elevated body temperature, hyperactivity, and/or high blood pressure can all be signs of serotonin syndrome. Fortunately, the development serotonin syndrome generally requires a combination of at least two serotonin-increasing drugs and rarely happens spontaneously with one medication but it is important to be aware of the symptoms as the high blood pressure can be life-threatening if severe enough. Using MAO inhibitors in conjunction with fluoxetine could create serotonin syndrome. MAO inhibitors are rarely used in veterinary patients with the exception of selegiline, a drug used for cognitive dysfunction in dogs, and amitraz, an anti-parasite topical which is used in several tick control products (see our tick product comparison chart) as well as in Mitaban® dip which is used against mange. Fluoxetine should not be given in conjunction with a Monoamine oxide inhibitor (“MAO inhibitor”) such as selegiline or amitraz.
Cyproheptadine, an appetite stimulant, may decrease or even reverse the effect of fluoxetine.
Fluoxetine should not be used in combination with drugs that could increase the likelihood of seizures (such as acepromazine).
Insulin requirements may be altered in the presence of fluoxetine.
CONCERNS AND CAUTIONS
Fluoxetine lasts a long time in the body. If planning to discontinue fluoxetine, a tapering course is not necessary unless the patient has been taking fluoxetine for more than 8 weeks. In that case, tapering the dose over a couple of weeks is a good idea.
Fluoxetine and MAO inhibitors should not be given together and a "wash out" period is needed between them. If one wishes to begin an MAO inhibitor (selegiline for cognitive dysfunction or amitraz for parasite control) in a patient presently on fluoxetine, a 5 week period is recommended between the last dose of fluoxetine and the first dose of the MAO inhibitor. Similarly, if a patient is on an MAO inhibitor and will be beginning fluoxetine, a two week period is needed between medications. The period is longer in the former incidence because of the very long half-life of fluoxetine in the body.
Page posted: 3/29/2021